Publication date: Aug 01, 2025
Radiotherapy is widely used in the treatment of early-stage laryngeal cancer (stage I and II). We analyzed the efficacy of conventional and accelerated fractionated radiotherapy (52. 5 Gy in 16 fractions) for early-stage laryngeal cancer retrospectively. We compared the outcomes of 25 patients treated with conventional fractionation (CF group: 66-70 Gy in 33-35 fractions) and 20 patients treated with accelerated fractionation (AF group: 52. 5 Gy in 16 fractions) radiotherapy from 2011 to 2024 at our institution. Local control rate was 87. 8% at five years in the CF group and 95% at five years in the AF group. Acute adverse events were significantly higher in the CF group, with 72% Grade 2 or higher dermatitis compared to 20% in the AF group (p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Laryngeal Cancer |
| disease | MESH | dermatitis |
| disease | MESH | COVID-19 pandemic |
| drug | DRUGBANK | Tropicamide |
| pathway | REACTOME | Reproduction |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | malignancy |
| drug | DRUGBANK | Methionine |
| disease | MESH | squamous carcinoma |
| disease | MESH | metastasis |
| disease | IDO | algorithm |
| disease | IDO | process |
| disease | MESH | death |
| disease | MESH | recurrence |
| disease | MESH | mucositis |
| drug | DRUGBANK | L-Aspartic Acid |
| disease | MESH | Renal failure |
| disease | MESH | COPD |
| disease | MESH | bleeding |
| disease | MESH | Dysphagia |
| drug | DRUGBANK | Morphine |
| disease | MESH | complications |
| disease | MESH | prostate cancers |
| disease | MESH | laryngeal edema |
| disease | MESH | necrosis |
| disease | MESH | sclerosis |
| disease | IDO | susceptibility |
| disease | MESH | carcinoma |
| disease | MESH | neck cancers |
| disease | MESH | arc |
| drug | DRUGBANK | 3 7 11 15-Tetramethyl-Hexadecan-1-Ol |
| disease | MESH | breast cancer |
| pathway | KEGG | Breast cancer |