Publication date: Sep 23, 2025
To further elucidate the effects of rare systemic autoimmune rheumatic diseases (SARD) and their treatment on antibody development after vaccination against SARS-CoV-2, we compared patients with and without immunosuppressive therapy to healthy controls in an observational cohort study. We enrolled 52 patients with SARD and 72 healthy subjects in a prospective, observational study at the Medical University of Vienna and measured the humoral response 6 months after two mRNA vaccinations and 2-6 weeks after a third dose. Patients with vasculitis showed significantly (p=0. 02) lower antibody titres 6 months after vaccination (median 247 BAU/mL, IQR [185-437]), as compared with healthy controls (median 514 BAU/mL, [185-437], IQR 323; 928, vasculitis patients: 247, IQR [185; 437], p
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | rheumatic disease |