Surveillance of Twitter Data on COVID-19 Symptoms During the Omicron Variant Period: A Sentiment Analysis.

Surveillance of Twitter Data on COVID-19 Symptoms During the Omicron Variant Period: A Sentiment Analysis.

Publication date: Sep 23, 2025

The global outbreak of COVID-19 has significantly impacted health care systems and has necessitated timely access to information for effective decision-making by health care authorities. Conventional methods for collecting patient data and analyzing virus mutations are resource-intensive. In the current era of rapid internet development, information on COVID-19 infections could be collected by a novel approach that leverages social media, particularly Twitter (subsequently rebranded X). The aim of this study was to analyze the trending patterns of tweets containing information about various COVID-19 symptoms, explore their synchronization and correlation with conventional monitoring data, and provide insights into the evolution of the virus. We categorized tweet sentiments to understand the predictive power of negative emotions of different symptoms in anticipating the emergence of new Omicron subvariants and offering real-time assistance to affected individuals. Relevant user tweets from 2022 containing information about COVID-19 symptoms were extracted from Twitter. Our fine-tuned RoBERTa model for sentiment analysis, achieving 99. 7% accuracy for sentiment analysis, was used to categorize tweets as negative, positive, or neutral. Joinpoint regression analysis was used to examine the trends in weekly negative tweets related to COVID-19 symptoms, aligning these trends with the transition periods of SARS-CoV-2 Omicron subvariants from 2022. Real-time Twitter users with negative sentiments were geographically plotted. A total of 105,934 tweets related to fever, 120,257 to cough, 55,790 to headache, 101,220 to sore throat, 3410 to vomiting, and 5913 to diarrhea were collected. The most prominent topics of discussion were fever, sore throat, and headache. The weekly average daily tweets exhibited different fluctuation patterns in different stages of subvariants. Specifically, fever-related negative tweets were more sensitive to Omicron subvariant evolution, while discussions of other symptoms declined and stabilized following the emergence of the BA. 2 variant. Negative discussions about fever rose to nearly 40% at the beginning of 2022 and showed 2 distinct peaks during the absolute dominance of BA. 2 and BA. 5, respectively. Headache and throat-related negative sentiment exhibited the highest levels among the analyzed symptoms. Tweets containing geographic information accounted for 1. 5% (1351/391,508) of all collected data, with negative sentiment users making up 0. 35% (5873/391,508) of all related tweets. This study underscores the potential of using social media, particularly tweet trends, for real-time analysis of COVID-19 infections and has demonstrated correlations with major symptoms. The degree of negative emotions expressed in tweets is valuable in predicting the emergence of new Omicron subvariants of COVID-19 and facilitating the provision of timely assistance to affected individuals.

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Concepts Keywords
Diarrhea COVID-19
Twitter COVID-19
Valuable geographic tracking
Weekly Humans
natural language processing
real-time analysis
SARS-CoV-2
sentiment analysis
Social Media
social media surveillance
Twitter
virus mutations

Semantics

Type Source Name
disease MESH COVID-19
disease MESH infections
disease MESH sore throat
disease MESH Long Covid
drug DRUGBANK Methylphenidate
drug DRUGBANK Ranitidine
disease MESH Infectious Diseases
disease IDO symptom
disease MESH panic
disease MESH influenza
disease MESH cholera
pathway REACTOME Reproduction
disease MESH dengue fever
disease MESH tics
disease MESH Middle East respiratory syndrome
disease IDO process
drug DRUGBANK Alpha-1-proteinase inhibitor
disease MESH reinfection
disease IDO infection
disease IDO intervention
disease IDO acute infection
drug DRUGBANK Icodextrin
disease MESH sequelae
disease MESH emergencies
disease IDO cell
drug DRUGBANK Coenzyme M
drug DRUGBANK Guanosine

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