Publication date: Sep 22, 2025
Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection. Approximately 7% of individuals who recover from SARS-Cov-2 infection develop Long COVID. Long COVID Postural Orthostatic Tachycardia Syndrome (LCPOTS) symptoms include fatigue, exercise intolerance, orthostatic intolerance, syncope, and heightened orthostatic tachycardia. Research has found that decreased parasympathetic activity in LCPOTS increases the production of highly immunogenic neoantigens Isolevuglandins (IsoLG-adducts). IsoLG-adducts induce formation of circulating monocyte/T cell complexes(doublets) leading to the persistent and unresolved immune response that continues after the initial infection. The purpose of the this research, is to study the effects of 2-hydroxybenzylamine (2-HOBA), an Iso-LG-adduct scavenger, its effects in immune markers and compare it with Placebo
| Concepts | Keywords |
|---|---|
| Immunocompromised | Long COVID |
| Influenza | |
| Professional | |
| Sleepiness | |
| Weeks |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | protein |
| disease | MESH | Long COVID |
| disease | MESH | SARS-CoV-2 infection |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | Postural Orthostatic Tachycardia Syndrome |
| disease | MESH | syncope |
| disease | MESH | tachycardia |
| disease | IDO | production |
| disease | IDO | cell |
| disease | IDO | immune response |
| disease | MESH | infection |
| disease | MESH | orthostatic hypotension |
| disease | MESH | influenza |
| disease | MESH | sore throat |
| disease | MESH | dyspnea |
| disease | MESH | anorexia |
| disease | IDO | history |
| disease | IDO | nucleic acid |
| disease | MESH | immunocompromised patients |
| disease | MESH | cardiovascular disease |
| disease | MESH | atrioventricular block |
| disease | MESH | myocardial infarction |
| disease | MESH | heart failure |
| disease | MESH | stroke |
| disease | MESH | transient ischemic attack |
| disease | MESH | hypertension |
| disease | MESH | type 2 diabetes mellitus |