Publication date: Oct 13, 2025
Background and Aims: Severe acute respiratory distress syndrome (ARDS) in patients with long COVID remains associated with extremely high mortality and significant long-term sequelae. Non-invasive ventilatory strategies such as continuous positive airway pressure (CPAP) and high-flow nasal cannula (HFNC) are widely used before endotracheal intubation (ETI). Still, their comparative effectiveness in this population is not well established. Understanding survival outcomes and sequelae can help refine treatment strategies for this high-risk group. This study aimed to evaluate outcomes, sequelae, and treatment strategies in long COVID patients with severe ARDS, focusing on non-invasive ventilatory support before ETI. Materials and Methods: A retrospective cohort analysis was performed using a study comparing severe ARDS patients with and without COVID-19. The inclusion criterion was a Horovitz quotient (PaO/FiO)
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| Concepts | Keywords |
|---|---|
| Accounting | COVID-19 |
| Covid | endotracheal intubation |
| Endotracheal | high-flow nasal cannula |
| Pulmonary | non-invasive ventilation |
| ventilation treatment |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Sequelae |
| disease | MESH | Long COVID |
| disease | MESH | acute respiratory distress syndrome |
| disease | MESH | COVID-19 |
| disease | MESH | dyspnea |
| disease | MESH | hypoxemia |