Relationship of Mediterranean Diet and Its Components with Parameters of Structure, Vascular Function, and Vascular Aging in Subjects Diagnosed with Long COVID: BioICOPER Study.

Relationship of Mediterranean Diet and Its Components with Parameters of Structure, Vascular Function, and Vascular Aging in Subjects Diagnosed with Long COVID: BioICOPER Study.

Publication date: Oct 14, 2025

Long COVID (LC) is associated with an increase in cardiovascular risk and chronic inflammation, whereas the Mediterranean Diet (MD) seems to improve the aforementioned factors. The aim of this study is to analyse the relationship between MD and its components with vascular structure, function, and aging in patients diagnosed with LC globally and by sex. This study was a cross-sectional study with 304 subjects diagnosed with LC; 207 were women and 97 men. Adherence to MD was evaluated with a validated MEDAS questionnaire, composed of 14 items. The vascular structure was assessed using carotid intima-media thickness (cIMT). Three measurements were carried out to evaluate vascular function: cardio-ankle vascular index (CAVI), brachial-ankle pulse wave velocity (baPWV), and carotid-femoral pulse wave velocity (cfPWV). Vascular aging index (VAI) was estimated. The MD score was 7. 80 +/- 2. 33, with no difference between sexes. Vascular function and aging parameter values were higher in men than in women. Use of olive oil as the principal source of fat for cooking, and consuming

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Concepts Keywords
Bioicoper Adult
Carotid Aged
Cooking Aging
Oil Ankle Brachial Index
Women Carotid Intima-Media Thickness
COVID-19
Cross-Sectional Studies
Diet, Mediterranean
Female
Humans
long COVID
Male
Mediterranean Diet
Middle Aged
Pulse Wave Analysis
SARS-CoV-2
Sex Factors
vascular aging
vascular function
Vascular Stiffness
vascular stiffness
vascular structure

Semantics

Type Source Name
disease MESH Long COVID
disease MESH cardiovascular risk
disease MESH inflammation
drug DRUGBANK Olive oil

Original Article

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