Red Blood Cell-Associated Features of Adenoviral Vector-Linked Venous Thrombosis.

Red Blood Cell-Associated Features of Adenoviral Vector-Linked Venous Thrombosis.

Publication date: Nov 29, 2025

Adenoviral vector vaccines were pivotal for COVID-19 control, but postmarketing safety surveillance has identified venous-predominant thrombotic risks not fully explained by platelet-centric mechanisms. We tested an RBC-associated hypothesis using an Ad5 vector-rAd/HA(PR8) rat model within a predefined sub-hemolytic window (

Concepts Keywords
Covid adenoviral vector vaccines
Postmarketing Adenoviridae
Red adenovirus type 5 (Ad5)
Thrombosis Animals
Vaccines COVID-19
COVID-19 Vaccines
COVID-19 Vaccines
Disease Models, Animal
Erythrocytes
Genetic Vectors
Humans
Male
Phosphatidylserines
Phosphatidylserines
Rats
RBC shape changes
red blood cells
SARS-CoV-2
Thrombin
Thrombin
thrombin generation
Venous Thrombosis
venous thrombosis

Semantics

Type Source Name
drug DRUGBANK Thrombin
disease MESH Disease Models Animal
disease MESH rAd
disease MESH Ad5
disease MESH COVID-19
disease MESH Venous Thrombosis

Original Article

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