Publication date: Dec 02, 2025
This indicates a distinct mechanism for Covid-19-related brain damage, involving synaptic dysfunction, inflammation, and oxidative stress. The study identified objective methods for diagnosing long Covids cognitive impairment. Their paper is titled Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of Covid-19. The research team plans to continue following Covid-19 patients with cognitive impairment in the long term. This may show impaired waste clearance and neuroinflammation. Blood tests revealed actual brain cell damage. While brain injury markers were high, key drivers of dementiaamyloid beta (A) and tau proteinwere not elevated. Previous studies on long Covid primarily focused on hospitalized, severely ill patients. The areas marked in red are the cingulate and insular cortex, presented in lateral, medial, and coronal views (top to bottom).
| Concepts | Keywords |
|---|---|
| 19mri | Acute |
| Dementiaamyloid | Brain |
| Korea | Cognitive |
| Nfl | Cortex |
| Professors | Covid |
| Damage | |
| Distinct | |
| Impairment | |
| Iron | |
| Long | |
| Mild | |
| Neurodegenerative | |
| Pasc | |
| Post | |
| Sequelae |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | IDO | cell |
| disease | MESH | oxidative stress |
| drug | DRUGBANK | Iron |
| disease | MESH | brain fog |
| disease | MESH | sequelae |
| disease | MESH | post-acute sequelae of Covid-19 |
| disease | MESH | cognitive impairment |
| disease | MESH | infection |
| disease | MESH | Covid-19 |
| disease | MESH | neuroinflammation |
| disease | IDO | blood |
| disease | MESH | atrophy |
| disease | MESH | dementia |
| disease | MESH | inflammation |
| disease | IDO | process |