Publication date: Nov 01, 2025
Coronavirus disease 2019 (COVID-19) has been associated with a range of neurological complications, including an increased risk of stroke. This study aimed to examine the relationship between COVID-19 and stroke risk in hospitalized patients. A retrospective cohort study was conducted involving 280 patients with COVID-19 and 300 non-COVID-19 controls. Sociodemographic data, medical history, COVID-19 characteristics, and inflammatory biomarkers were analyzed using chi-square tests and unpaired Student’s t-tests to assess associations with stroke occurrence. Sociodemographic factors, including age, sex, smoking status, and prevalence of chronic conditions, did not significantly differ between the two groups (p > 0. 05). However, COVID-19 patients exhibited a higher prevalence of ischemic stroke (n = 17, 6. 07%), hemorrhagic stroke (n = 4, 1. 43%), and cerebral venous thrombosis (n = 3, 1. 07%) compared to non-COVID-19 controls (p = 0. 019). Severe COVID-19, prolonged illness (>2 weeks), low oxygen saturation (
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| Concepts | Keywords |
|---|---|
| Biomarkers | covid-19 |
| Coronavirus | cytokine storm |
| Covid | interleukin (il)-6 |
| Hemorrhagic | intracranial hemorrhage (ich) |
| Low | ischemic stroke |
| pandemic | |
| stroke | |
| stroke mortality | |
| world pandemic |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | Stroke |
| disease | MESH | chronic conditions |
| disease | MESH | ischemic stroke |
| disease | MESH | hemorrhagic stroke |
| drug | DRUGBANK | Oxygen |
| pathway | REACTOME | Reproduction |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | Dyslipidemia |
| disease | MESH | hypertension |
| disease | MESH | diabetes mellitus |
| disease | MESH | atrial fibrillation |
| disease | MESH | ischemic heart disease |
| disease | MESH | cytokine storm |
| disease | MESH | inflammation |
| disease | MESH | intracranial hemorrhage |
| disease | MESH | ich |