SON4PEM Study: Sonlicromanol in Post-COVID: A Randomized, Double-blind, Placebo-controlled, Phase II Trial

Publication date: Dec 11, 2025

The aim of this randomized, doube-blind, placebo-controlled, phase II trial, is to study the effect of sonlicromanol on fatigue in paticEBnt with post-COVID who experience post-exertional malaise (PEM).

Concepts	Keywords
Grapefruit	Blind
Hepatitis	Controlled
Nsaid	Covid
Organic	Criteria
Son4pem	Infection
	Medication
	Pem
	Phase
	Placebo
	Post
	Randomized
	Son4pem
	Sonlicromanol
	Study
	Trial

Semantics

Type	Source	Name
disease	MESH	fatigue
disease	MESH	SARS-CoV-2 infection
pathway	REACTOME	SARS-CoV-2 Infection
pathway	REACTOME	Cardiac conduction
disease	MESH	cardiovascular disease
disease	MESH	psychiatric disorder
disease	MESH	substance
disease	MESH	malignancy
disease	MESH	hepatitis B
pathway	KEGG	Hepatitis B
pathway	REACTOME	Vitamins
drug	DRUGBANK	Vitamin E
drug	DRUGBANK	Riboflavin
drug	DRUGBANK	Amino acids
drug	DRUGBANK	Valproic Acid
drug	DRUGBANK	Amiodarone
drug	DRUGBANK	Carbamazepine
drug	DRUGBANK	Phenobarbital
drug	DRUGBANK	Phenytoin
drug	DRUGBANK	Rifampicin
drug	DRUGBANK	St. John’s Wort
drug	DRUGBANK	Pioglitazone
drug	DRUGBANK	Troglitazone
drug	DRUGBANK	Azithromycin
drug	DRUGBANK	Captopril
drug	DRUGBANK	Clarithromycin
drug	DRUGBANK	Ciclosporin
drug	DRUGBANK	Piperine
drug	DRUGBANK	Quercetin
drug	DRUGBANK	Quinidine
drug	DRUGBANK	Quinine
drug	DRUGBANK	Reserpine
drug	DRUGBANK	Ritonavir
drug	DRUGBANK	Tariquidar
drug	DRUGBANK	Verapamil