Utilizing the DMN and DAN to study the effects of acupuncture on patients with cognitive impairment in long COVID: a pragmatic randomized controlled trial protocol.

Publication date: Dec 08, 2025

Background Cognitive impairment is one of the long COVID symptoms that many people experience after Coronavirus Disease 2019 (COVID-19). Many individuals report a decline in cognitive functions, such as reduced memory and brain fog. These symptoms not only directly affect the cognitive functions of the brain but also hinder daily living activities, thereby reducing the quality of life. Moreover, these symptoms are significant risk factors for long-term cognitive decline in the elderly and can have both short-term and long-term effects on brain function. Clinically, acupuncture is widely used to improve cognitive impairment in the elderly. Elucidating the brain network mechanisms underlying acupuncture therapy for Long COVID-related cognitive impairment represents an urgently needed research focus. In this study, we employed acupuncture as an intervention to mitigate cognitive decline in Long COVID patients and investigate the potential mechanisms by which acupuncture alleviates cognitive impairment. Methods In this randomized controlled trial, 60 eligible participants are planned to be recruited and randomly assigned in a 1:1 ratio to the acupuncture group and the health education group, which will then receive acupuncture treatment and health education. The acupuncture group will participate in treatment three times per week for a total of eight weeks. The health education group will receive health education once per week for a total of eight weeks. The primary assessment index was the Montreal Cognitive Assessment Scale (MoCA), and the secondary assessment indexes included Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), Activity of Daily Living Scale (ADL), Auditory Verbal Learning Test – Huashan Version (AVLT-H) and resting-state functional magnetic resonance imaging (rs-fMRI) data. These assessment indicators were all tested in one week each before and after the intervention was implemented. Discussion This trial aims to investigate the therapeutic effects of acupuncture on cognitive impairment in patients with long COVID and to further explore the imaging mechanisms by which acupuncture alleviates cognitive dysfunction in these patients. Trial registration: Chinese Clinical Trial Registry (http://www,chictr,org. cn), Registration number: ChiCTR2400092961,Date of Reqistration: 2024-11-26.

Semantics

Original Article