Publication date: Dec 11, 2025
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a life-threatening respiratory illness that shares clinical similarities with autoimmune diseases, which some patients subsequently develop. We herein report a case of an older Japanese patient who presented with skin rash, relapsing progressive interstitial lung disease, and anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody seropositivity after COVID-19 infection. Although the patient was elderly, her symptoms improved with the administration of corticosteroids, tacrolimus, and intravenous cyclophosphamide, indicating that this combination may be a viable treatment option for anti-MDA5 antibody-positive pneumonia, which is a complication of COVID-19.
| Concepts | Keywords |
|---|---|
| Amyopathic | amyopathic dermatomyositis |
| Cyclophosphamide | autoimmune diseases |
| Japanese | coronavirus disease 2019 |
| Pneumonia | intravenous cyclophosphamide |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | melanoma |
| pathway | KEGG | Melanoma |
| disease | MESH | amyopathic dermatomyositis |
| disease | MESH | COVID-19 |
| pathway | KEGG | Coronavirus disease |
| disease | MESH | severe acute respiratory syndrome |
| disease | MESH | autoimmune diseases |
| disease | MESH | skin rash |
| disease | MESH | interstitial lung disease |
| disease | MESH | infection |
| drug | DRUGBANK | Tacrolimus |
| drug | DRUGBANK | Cyclophosphamide |
| disease | MESH | pneumonia |
| disease | MESH | Long Covid |