Publication date: Dec 09, 2025
Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV), an emerging bat-origin Alphacoronavirus with demonstrated zoonotic potential, poses a significant threat to swine health and has considerable economic implications. Currently, no licensed vaccines are available. We constructed a replication-deficient human adenovirus type 5 (Ad5) vectored vaccine candidate, rAd5-SADS-S, which expresses the SADS-CoV Spike (S) glycoprotein. The rAd5-SADS-S vaccine elicited robust SADS-CoV-specific humoral immunity and potent cellular responses in both mice and pigs. Notably, rAd5-SADS-S conferred passive protection to neonatal mice against lethal SADS-CoV challenge. These findings establish a preclinical foundation for the development of SADS-CoV vaccines.
| Concepts | Keywords |
|---|---|
| Alphacoronavirus | Adenovirus vector |
| Economic | Spike protein |
| Lethal | Vaccine |
| Mice | |
| Vaccine |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | diarrhea |
| disease | MESH | syndrome |
| disease | MESH | Ad5 |