Publication date: Nov 21, 2025
Background/Objectives: Whether a remote history of SARS-CoV-2 infection independently affects early haemodynamic stability after elective cardiopulmonary bypass (CPB) remains uncertain. We evaluated whether prior COVID-19 (>7 weeks before surgery) was associated with postoperative vasopressor requirements or early complications in adults undergoing elective CPB. Methods: We conducted a single-centre prospective cohort study including adults (≥18 years) scheduled for elective on-pump coronary, valve, or combined cardiac surgery between 1 August 2022 and 30 October 2023. Patients undergoing emergency procedures or surgery 7 weeks preoperatively. The primary outcome was postoperative vasopressor use within 24 h of ICU admission; secondary outcomes included inotrope use, arrhythmias, acute cardiac or respiratory failure, pneumonia, acute kidney injury (KDIGO), delirium, stroke, length of stay, and mortality. Multivariable logistic regression adjusted for age, CPB duration, obesity, anaemia, chronic kidney disease, sex, EuroSCORE I, left ventricular ejection fraction, and procedure type. Results: Of 351 screened patients, 280 elective CPB cases were analyzed; 101 (36. 1%) had prior COVID-19. Vasopressor use occurred in 151/280 (53. 9%) patients, with no difference between COVID and non-COVID groups (53. 5% vs. 54. 2%; p = 1. 00). Prior COVID-19 was not associated with vasopressor requirement (adjusted OR 0. 94, 95% CI 0. 56-1. 59). Independent predictors were longer CPB duration (aOR 2. 80 per hour; p
| Concepts | Keywords |
|---|---|
| August | cardiac surgery |
| Obesity | cardiopulmonary bypass |
| October | COVID-19 |
| Pneumonia | perioperative |
| Surgery | vasopressors |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | emergency |
| disease | MESH | infection |
| disease | MESH | included |
| disease | MESH | respiratory failure |
| disease | MESH | pneumonia |
| disease | MESH | acute kidney injury |
| disease | MESH | delirium |
| disease | MESH | stroke |
| disease | MESH | obesity |
| disease | MESH | chronic kidney disease |
| disease | MESH | postoperative complications |