Publication date: Dec 18, 2025
It interacts with the host cell in an extremely sophisticated and direct manner, manipulating its genetic material like no other pathogen does. This technology works by monitoring changes in an electric current as nucleic acids the molecules that make up genetic material pass through a protein nanopore. “This changes our understanding of the virus and of RNA viruses and paves the way for new prevention and treatment strategies. The virus quickly establishes connections with lncRNAs, such as UCA1, GAS5, and NORAD, upon invading the cell. “In the study, we identified the lncRNA UCA1 as a central player exhibiting a complex pattern of reduced expression and increased methylation. Using machine learning techniques, the researchers measured the overall increase in methylation in cells. This process destabilizes RNA structures and hinders the classic pairing between the amino acid bases adenine (A) and uracil (U).
| Concepts | Keywords |
|---|---|
| Bioinformatics | Briones |
| Brazil | Cell |
| Mathematician | Cov |
| Viral | Genetic |
| Weakening | Host |
| Immune | |
| Interacts | |
| Interferon | |
| Invading | |
| Lncrnas | |
| Material | |
| Methylation | |
| Sars | |
| Sophisticated | |
| Virus |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Propylthiouracil |
| drug | DRUGBANK | Uracil |
| drug | DRUGBANK | Adenine |
| pathway | REACTOME | Interferon Signaling |
| pathway | REACTOME | Methylation |
| disease | MESH | COVID-19 |
| pathway | REACTOME | Immune System |