Publication date: Dec 17, 2025
We applied a voxel-based personalized dosimetry method using multiple voxel S-values (VSVs) to assess the intratumoral dose distribution in hepatocellular carcinoma (HCC) patients treated with trans-arterial radioembolization (TARE) using glass microspheres. This study aimed to evaluate the predictive value of dose metrics for treatment response and local progression-free survival (L-PFS). Ninety patients with HCC who underwent TARE between November 2015 and December 2019 were retrospectively analyzed. Post-treatment Y-microsphere PET/CT images were used to generate voxel-wise absorbed dose maps via convolution with CT-derived multiple VSV kernels. Tumor volumes were manually delineated on contrast-enhanced CT co-registered with dose map. Dose-volume histogram (DVH) parameters, including V-V (tumor volume receiving
| Concepts | Keywords |
|---|---|
| December | Hepatocellular carcinoma |
| Microsphere | Trans-arterial radioembolization |
| Ninety | Tumor heterogeneity |
| Predictive | Voxel-based dosimetry |
| Tumor |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | hepatocellular carcinoma |
| pathway | KEGG | Hepatocellular carcinoma |
| disease | MESH | VSVs |
| disease | MESH | glass |
| disease | MESH | Tumor |