Publication date: Dec 23, 2025
Membrane fusion is crucial for the entry of enveloped viruses into host cells. SARS-CoV contains multiple fusion peptide-like sequences, which could interact with each other, resulting in its high infectivity. Here, we report the interaction between the N-terminal (FP) and the internal fusion peptides (IFP1) of SARS-CoV, which has a significant impact on membrane fusion. We found that the interaction depends on the cholesterol (CH) content of the membrane.
| Concepts | Keywords |
|---|---|
| Cholesterol | Cholesterol |
| Crucial | Cov |
| Host | Crucial |
| Peptides | Dependent |
| Viruses | Entry |
| Enveloped | |
| Fusion | |
| Implications | |
| Interaction | |
| Internal | |
| Membrane | |
| Peptides | |
| Sars | |
| Terminal |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Cholesterol |
Original Article
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