Publication date: Dec 20, 2025
Hip fractures (HF) are among the most prevalent diagnoses in geriatric traumatology, with persistently high incidence even during the COVID-19 pandemic. Concomitant SARS-CoV-2 infection adds clinical complexity and has been associated with increased mortality and prolonged hospitalisation. This study aimed to assess the impact of SARS-CoV-2 subvariants B. 1.1. 7 (Alpha), B. 1.617. 2 (Delta), and B. 1.1. 529 (Omicron) on postoperative outcomes in patients undergoing surgical treatment for HF. A retrospective multicentre study was conducted using data from the German Registry for Geriatric Trauma (ATR-DGU) between March 2021 and April 2022 across 119 hospitals. 12,707 patients undergoing HF surgery were included and stratified by predominant subvariant periods: Alpha (n = 3714), Delta (n = 5434), and Omicron (n = 3559). Each cohort was further stratified by SARS-CoV-2 status at admission. During the Alpha period, in-hospital mortality and length of stay were similar between COVID-19-comorbid (8. 3%, 13 days) and SARS-CoV-2-negative patients (5. 4%, 15 days). In the Delta and Omicron periods, mortality was significantly higher among COVID-19-comorbid patients (14. 3% and 13. 9%) compared to SARS-CoV-2-negative patients (5. 8%, p = 0. 017; 5. 7%, p
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| Concepts | Keywords |
|---|---|
| April | COVID-19 |
| German | Hip fracture |
| Multinational | Orthogeriatric management |
| Surgery | Proximal femur fracture |
| SARS-CoV-2 |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Hip fractures |
| disease | MESH | COVID-19 pandemic |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | Trauma |
| disease | MESH | included |
| disease | MESH | Long Covid |
| pathway | REACTOME | Reproduction |
| disease | MESH | Proximal femur fracture |