Publication date: Jan 01, 2026
The innate immune system serves as the first line of defense for the host against microbial invasion. Toll-like receptors (TLRs), are pathogen pattern recognition receptors can initiate signal cascades to mediate innate immune responses; however, the mechanism of TLR2 in viral infections remains unclear. This study aimed to clarify the impact of TLR2 deficiency on the pathogenesis of Porcine Epidemic Diarrhea Virus (PEDV) infection and host immune defense. Through transcriptome analysis, the abnormal molecular expression profiles induced by TLR2 deficiency in PEDV-infected bone marrow-derived dendritic cells (BMDCs) was characterised, including aberrant activation of the non-canonical nuclear factor-kappa B (NF-_705B) signaling pathway, dysregulated expression of MHC Class Ⅰ/Ⅱ genes, and disordered apoptotic signaling. To verify the effects of these molecular characteristics on cellular functions, further detection using flow cytometry revealed the following: in terms of maturation and activation, TLR2 deficiency significantly reduced the surface levels of CD40, CD86, and CD83 in PEDV-infected BMDCs (p
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | diarrhea |
| disease | MESH | virus infection |
| pathway | REACTOME | Innate Immune System |
| disease | MESH | infection |
| pathway | REACTOME | Apoptosis |
| disease | MESH | Coronavirus Infections |
| pathway | REACTOME | Signal Transduction |
| disease | MESH | Swine Diseases |