Publication date: Dec 23, 2025
Post-COVID-19 Syndrome (PCS) is associated with persistent fatigue and cognitive symptoms that may disrupt daily functioning and mental health. This study examined interrelationships among fatigue, cognitive function, activity and role functioning, and mental health in individuals with PCS. We analyzed cross-sectional data from 535 adults in the Quebec Action for Post-COVID (QAPC) cohort who self-identified as experiencing PCS symptoms. Structural Equation Modelling was used to estimate associations among fatigue, self-reported cognitive concerns, cognitive performance, and two latent constructs: activity and role functioning and mental health. Models were adjusted for age, sex, education, race, alcohol use, prior mental health history, and vaccination status. Fatigue showed association with mental health (standardized regression coefficient, β_std = 0. 44, p
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | fatigue |
| disease | MESH | cognitive dysfunction |
| disease | MESH | post-COVID-19 syndrome |
| disease | MESH | PCS |
| disease | MESH | cognitive symptoms |
| disease | MESH | COVID-19 |