Publication date: May 16, 2026
Next-generation sensing technologies require high-performance sensors that offer ultra-low loss with enhanced sensitivity. To achieve this, we propose a hollow-core anti-resonant fiber (HC-ARF) refractive index (RI) sensor utilizing the surface plasmon resonance (SPR) detection mechanism for superior optical sensing performance. The proposed sensor model features a single ring of uniformly arranged regular cladding tubes, each coated with a thin plasmonic metal layer to facilitate strong coupling between the core and surface plasmon modes. Through rigorous finite-element modeling (FEM) simulations, the fiber structure is carefully optimized and sensing performance is investigated to obtain ultra-low loss and high detection sensitivity via wavelength interrogation. The simulation results show that the proposed HC-ARF sensor achieves losses up to two orders of magnitude lower than conventional solid-core fiber sensors. Notably, the sensor achieves enhanced wavelength sensitivity (WS) of 6500 and 11,500 nm/RIU for analyte RIs of 1. 33 and 1. 43, respectively, effectively spanning the visible to near-infrared spectrum with a broad sensing range from 1. 25 to 1. 44. Moreover, it shows stable performance under tight bending conditions with 10 cm bend radius and +/-4% variations in geometric parameters. The combination of relatively low-loss, wide detection range, and high sensing performance makes this sensor effective for real-time RI monitoring applications such as glucose and sucrose concentration analysis, cancer cell detection, and SARS-CoV-2 identification.

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| Concepts | Keywords |
|---|---|
| Analyte | Anti |
| Glucose | Core |
| Physics | Detection |
| Strong | Fiber |
| High | |
| Hollow | |
| Loss | |
| Low | |
| Plasmonic | |
| Resonant | |
| Sensing | |
| Sensitivity | |
| Sensor | |
| Sensors | |
| Simulation |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Dextrose unspecified form |
| drug | DRUGBANK | Sucrose |
| disease | MESH | cancer |
| pathway | REACTOME | Reproduction |
| disease | MESH | included |
| drug | DRUGBANK | Silicon dioxide |
| drug | DRUGBANK | Medical air |
| disease | MESH | glass |
| drug | DRUGBANK | Gold |
| drug | DRUGBANK | Water |
| drug | DRUGBANK | Guanosine |
| drug | DRUGBANK | Droxidopa |
| drug | DRUGBANK | Sulpiride |
| drug | DRUGBANK | Aspartame |
| drug | DRUGBANK | Isoxaflutole |
| drug | DRUGBANK | Silver |
| drug | DRUGBANK | Copper |
| disease | MESH | Blood cancer |
| disease | MESH | Adrenal gland cancer |
| disease | MESH | Skin cancer |
| disease | MESH | Cervical cancer |
| disease | MESH | Breast cancer |
| pathway | KEGG | Breast cancer |
| disease | MESH | Park |
| drug | DRUGBANK | Thyroglobulin |
| drug | DRUGBANK | Albendazole |
| disease | MESH | glycosuria |
| drug | DRUGBANK | Vorinostat |
| disease | MESH | severe acute respiratory syndrome |