Publication date: May 22, 2026
Heterotopic ossification (HO) is common following acetabular surgery. Evidence comparing external beam radiation (XRT) and nonsteroidal anti-inflammatory drugs (NSAIDs) for HO prophylaxis remains conflicting. This study evaluated changes in XRT utilization during the COVID-19 pandemic and compared the efficacy of XRT versus NSAIDs. A retrospective review was conducted of 180 patients undergoing open acetabular fracture fixation at a level 1 trauma center from 2018 to 2021. High-risk patients received XRT or indomethacin if XRT was declined. Outcomes included prophylaxis method, severe (Brooker 3 or 4) HO, and HO resection. XRT utilization decreased significantly during the pandemic (74. 3% vs. 28. 0%, P
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | heterotopic ossification |
| disease | MESH | COVID-19 pandemic |
| drug | DRUGBANK | Tricyclazole |
| disease | MESH | trauma |
| drug | DRUGBANK | Indometacin |
| disease | MESH | included |
| disease | MESH | Fractures Bone |
| disease | MESH | Postoperative Complications |
Original Article
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