Publication date: Jun 01, 2026
While the acute phase of the COVID-19 pandemic has passed, understanding its pathophysiology remains critical for managing long-term sequelae and future viral threats. Oxidative stress is a proposed key driver of COVID-19 severity, but its relationship with the dynamic inflammatory cascade and its value as a standalone biomarker requires further validation. Case-control study was conducted to quantify systemic oxidative stress burden in 109 hospitalized COVID-19 patients (56 severe, 53 mild-moderate) and 112 healthy controls. Serum total oxidant status (TOS) and total antioxidant status (TAS) were measured, and the oxidative stress index (OSI) was calculated and correlated to the inflammatory mediators (IL-6, IL-8, IL-10, IP-10, CRP, SAA). COVID-19 patients exhibited a profound redox imbalance, characterized by elevated TOS and OSI, and depleted TAS compared to controls (p
| Concepts | Keywords |
|---|---|
| Biomarker | Biomarker |
| Pathophysiology | Cytokine storm |
| Viral | Inflammation |
| Oxidative stress | |
| SARS-CoV-2 |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| drug | DRUGBANK | Interleukin-10 |
| disease | MESH | Cytokine storm |
| disease | MESH | Inflammation |