Identification of Anti-Viral Compounds from Toxicodendron vernicifluum Extract That Inhibit the Coronavirus Replication.

ingentiumby ingentium

In Discovery Literature.

Publication date: Jun 01, 2026

Coronavirus can cause diseases ranging from mild cough to severe COVID-19. Although vaccines and antiviral agents for coronaviruses are available, alternative strategies are still needed to address emerging variants in the future. Toxicodendron vernicifluum is known to be rich in flavonoids, which exhibit antioxidant, anti-inflammatory, anticancer, and antiviral activities. However, the antiviral activity of T. vernicifluum against coronaviruses has not been fully investigated. Here, we report that the T. vernicifluum ethanol extract (TVE) shows antiviral effects against human coronavirus. TVE treatment inhibited coronavirus replication as well as viral infectivity. To elucidate the active constituents responsible for this activity, comprehensive phytochemical profiling of TVE was performed using UPLC-Q-Orbitrap-MS, leading to the tentative identification of major phytochemicals. Based on this analytical profiling, individual compounds were isolated from TVE and evaluated for antiviral activity against coronavirus. We found that ethyl gallate, fisetin, butin, sulfuretin, and gallic acid exhibit antiviral activity against coronavirus.

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Concepts Keywords
Antioxidant Antiviral
Biotechnol Coronavirus
Coronaviruses Fisetin
Ethanol HCoV-OC43
Rich Toxicodendron vernicifluum

Semantics

Type Source Name
disease MESH cough
disease MESH COVID-19
drug DRUGBANK Ethanol
drug DRUGBANK Fisetin
disease MESH Park4
disease MESH Park1
disease MESH upper respiratory infections
disease MESH common cold
disease MESH strains
disease MESH recurrent infections
drug DRUGBANK Diphenylpyraline
disease MESH allergic reactions
disease MESH influenza
drug DRUGBANK Medical air
drug DRUGBANK Flunarizine
drug DRUGBANK Formic Acid
drug DRUGBANK Water
disease MESH included
disease MESH Coronavirus Infection
disease MESH rhabdomyosarcoma
disease MESH FBS
drug DRUGBANK Streptomycin
disease MESH infection
drug DRUGBANK Methylergometrine
drug DRUGBANK Gentian violet cation
drug DRUGBANK Aspartame
drug DRUGBANK Sodium lauryl sulfate
disease MESH SDS
disease MESH Rad
disease MESH dehydration
drug DRUGBANK Platinum
pathway KEGG Virion
drug DRUGBANK Proline
drug DRUGBANK Beta-D-Glucose
drug DRUGBANK Taxifolin
disease MESH TIC
drug DRUGBANK Tannic acid
pathway KEGG Viral replication
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH Park
drug DRUGBANK Green tea leaf
drug DRUGBANK Epigallocatechin gallate
disease MESH Lung Cancer
disease MESH tumor
disease MESH metastasis
disease MESH carcinoma
drug DRUGBANK Isoflavone
drug DRUGBANK Sambucus nigra flower

Original Article

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