Sudden sensorineural olfactory loss: a structured narrative review and proposal for a standardised terminological framework.

Publication date: Mar 25, 2026

Sudden loss of smell – particularly when sensorineural in origin – is a clinically disabling condition that the medical community has never adequately named. Patients presenting with acute olfactory loss encounter a field without shared definitions, dedicated ICD codes, or guidelines built around their specific presentation. The consequence is diagnostic delay, terminological inconsistency in the literature, and a research base that cannot be meaningfully synthesised. This paper reviews the evidence on sudden sensorineural olfactory loss, demonstrates that existing terminology is inadequate, and proposes a single new clinical term: Sudden Sensorineural Olfactory Loss (SSNOL). Two descriptive aetiological categories are introduced solely to guide future research, not as additional terminology. A structured narrative review was conducted using PubMed, Embase, and Scopus databases. Studies were selected based on relevance to sudden olfactory dysfunction, neural pathway mechanisms, diagnostic imaging, and clinical management. Both primary research articles and systematic reviews published between 2000 and 2024 were considered. The evidence describes a condition with serious, sometimes permanent neural consequences. Post-viral olfactory loss – which received relatively limited specialist attention before the COVID-19 pandemic – was suddenly experienced by hundreds of millions of people, exposing how poorly the field was equipped to respond. Diagnostic tools are blunt. Treatment options are thin. Olfactory training is the only intervention with consistent evidence behind it. None of this will improve without better terminology to organise research around. We propose the term “Sudden Sensorineural Olfactory Loss” (SSNOL) as the sole terminological contribution of this paper, modelled on the established precedent of sudden sensorineural hearing loss (SSNHL). To guide future research, two descriptive aetiological categories are described – SSNOL-Viral and SSNOL-Idiopathic – presented as hypothesis-generating models to support future research design. Traumatic olfactory loss is explicitly excluded from the SSNOL definition and should be managed under existing post-traumatic frameworks.

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Concepts Keywords
anosmia
corticosteroids
COVID-19
ICD-11
olfactory dysfunction
olfactory training
post-viral anosmia
sensorineural smell loss
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Semantics

Type Source Name
disease MESH loss of smell
disease MESH ICD
disease MESH COVID-19 pandemic
drug DRUGBANK Tropicamide
disease MESH sensorineural hearing loss
pathway REACTOME Reproduction
drug DRUGBANK Medical air
disease MESH hearing loss
disease MESH included
disease MESH scarring
disease MESH trauma
disease MESH head trauma
drug DRUGBANK Sulpiride
disease MESH traumatic brain injury
disease MESH barotrauma
disease MESH syndrome
disease MESH viral infection
disease MESH atrophy
disease MESH Parosmia
disease MESH ect
drug DRUGBANK Sodium Citrate
drug DRUGBANK Lipoic Acid
disease MESH PRP
disease MESH Kallmann syndrome
disease MESH meningioma
disease MESH PVOD
disease MESH sudden hearing loss
disease MESH nasal polyps
disease MESH fatigue
disease MESH cognitive symptoms
disease MESH long COVID
disease MESH contusion
drug DRUGBANK Methionine
disease MESH calculus
disease MESH plan
disease MESH ERS
disease MESH ARS
disease MESH confusion
disease MESH APC
drug DRUGBANK Tromethamine
disease MESH Allergy
disease MESH infection
disease MESH MST
disease MESH mild traumatic brain injury
disease MESH Refsum Disease
drug DRUGBANK Oxytocin
drug DRUGBANK Calcium
disease MESH Parkinson’s disease
drug DRUGBANK Ginkgo biloba
drug DRUGBANK Mometasone
drug DRUGBANK Carboxyamidotriazole

Original Article

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