Publication date: Jun 18, 2026
Coronavirus macrodomains (Mac1) counter host immunity by removing ADP-ribose. GS-441524, the parent nucleoside of remdesivir, inhibits SARS-CoV-2 Mac1, but its active metabolite and cellular engagement were undefined. GS-441524 selectively inhibits SARS-CoV-2 Mac1 over human MacroD2, engages Mac1 in cells but not MERS-CoV Mac1, with its diphosphate metabolite being most potent.
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| Concepts | Keywords |
|---|---|
| Coronavirus | Cellular |
| Enhanced | Coronavirus |
| Host | Counter |
| Macrod2 | Cov |
| Diphosphorylated | |
| Engagement | |
| Enhanced | |
| Gs | |
| Inhibition | |
| Inhibits | |
| Mac1 | |
| Macrodomain | |
| Macrodomains | |
| Metabolite | |
| Sars |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | viral infection |
| disease | MESH | rubella |
| disease | MESH | hepatitis |
| disease | MESH | dis |
| disease | MESH | COVID 19 pandemic |
| drug | DRUGBANK | Adenosine-5-Diphosphoribose |
| drug | DRUGBANK | Flunarizine |
| drug | DRUGBANK | Coenzyme M |
| drug | DRUGBANK | Dimethyl sulfoxide |
| disease | MESH | infection |
| drug | DRUGBANK | Phosphate ion |
| drug | DRUGBANK | Adenosine |
| drug | DRUGBANK | Adenine |
| drug | DRUGBANK | Water |
| drug | DRUGBANK | Proline |
| disease | MESH | MES |
| drug | DRUGBANK | Sodium lauryl sulfate |
| disease | MESH | SDS |
| drug | DRUGBANK | Esomeprazole |
| disease | MESH | Image |
| drug | DRUGBANK | Dextrose unspecified form |
| drug | DRUGBANK | Histidine |
| drug | DRUGBANK | Cysteamine |
| disease | MESH | ham |
| disease | MESH | included |
| drug | DRUGBANK | Ilex paraguariensis leaf |
| pathway | KEGG | Viral replication |
| disease | MESH | infectious diseases |
| disease | MESH | severe acute respiratory syndrome |
| disease | MESH | coronavirus infection |
| drug | DRUGBANK | L-Isoleucine |
| drug | DRUGBANK | Troleandomycin |
| pathway | REACTOME | Metabolism |
| drug | DRUGBANK | Diethylstilbestrol |
| disease | MESH | Des |
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