Publication date: Apr 01, 2026
Clinical characteristics and humoral immune responses in pregnant women following natural SARS-CoV-2 Omicron infection remain unclear, particularly in those previously receiving inactivated vaccines, which may induce immune imprinting and affect cross-neutralization against emerging Omicron subvariants. This cross-sectional investigation was conducted in Zhejiang Province between December 2022 and April 2023. A total of 223 pregnant women with a gestational age of at least six weeks and 31 healthy non-pregnant women were recruited as research subjects and controls. Serum specimens were collected to determine anti-RBD IgG levels by ELISA, alongside pseudovirus neutralizing antibody titers against the prototype strain and Omicron BA. 4/5, XBB. 1.5 subvariants. Relevant clinical information was gathered through questionnaires, and multivariate regression analysis was applied to identify influencing factors of immune response characteristics. Acute COVID-19 symptom profiles were comparable between pregnant women and non-pregnant healthy women (P > 0. 05). Among questionnaire respondents, pregnant individuals had markedly prolonged symptom recovery, with a notably higher proportion taking over one week to recover (73. 0% vs. 23. 1%, P = 0. 045), and presented a significantly higher medical consultation rate (73. 0% vs. 15. 4%, P
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Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 pandemic |
| disease | MESH | infection |
| disease | MESH | strain |
| pathway | REACTOME | SARS-CoV-2 Infection |
| drug | DRUGBANK | Coenzyme M |
| pathway | REACTOME | Reproduction |
| disease | MESH | Infectious Disease |
| pathway | REACTOME | Infectious disease |
| disease | MESH | severe acute respiratory syndrome |
| disease | MESH | clinical progression |
| disease | MESH | breakthrough infection |
| disease | MESH | ADCC |
| disease | MESH | PBS |
| disease | MESH | Coronavirus Infections |
| disease | MESH | Pregnancy Complications Infectious |