Factors associated with return-to-sport outcomes following pathogen-confirmed acute respiratory infections in athletes: AWARE X study.

Publication date: Jun 19, 2026

To identify factors associated with return-to-sport (RTS) outcomes following confirmed acute respiratory infections (ARinf) in athletes. This prospective cohort study included 114 confirmed ARinf cases among athletic individuals. Causative pathogens were identified using multiplex PCR testing, and illness severity was classified per International Olympic Committee consensus (mild, moderate and severe). RTS outcomes included time (days) to return-to-training (RTT), return-to-full-training (RTFT) and return-to-full-performance (RTFP). Cox regression models (HRs) assessed associations between RTS outcomes and demographics, sport participation, pathogen groups and illness severity. The median (IQR) days to RTT were 3. 5 (0-7), RTFT 8 (6-11) and RTFP 11 (7-14). Amateur athletes had prolonged RTS outcomes (HR range=0. 51-0. 59; p≤0. 03) compared with professional athletes. RTS outcomes differed between the most common pathogen groups: influenza and SARS-CoV-2 had longer RTS than rhinovirus (HR range=0. 11-0. 23; p≤0. 003). Severe illness was associated with prolonged RTS outcomes compared with mild and moderate illnesses (HR range=0. 17-0. 31; p

Concepts Keywords
Models Athletes
Olympic Infection
Pcr Respiratory System
Rhinovirus Sports medicine
Severe Viruses

Semantics

Type Source Name
disease MESH respiratory infections
disease MESH RTS
disease MESH included
disease MESH HRs
disease MESH influenza
disease MESH Infection

Original Article

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