Outcomes of dyadic recruitment in the promoting re-engagement in meaningful activity (PRIMA) trial.

Publication date: Jun 23, 2026

Recruitment plays a critical role in the success of a clinical trial, but recruiting older persons with cognitive impairment (PwCI)-caregiver (CG) dyads for behavioral intervention studies during the COVID-19 pandemic presented challenges. We explore recruitment strategies and sources for an evidence- and telephone-based, tailored activity engagement, and skill-building randomized control trial involving older PwCI-CG dyads. Multiple recruitment sources and strategies were used, including direct/in-clinic referrals, healthcare system databases, and advertisements through established internal and external connections, and research partnerships. A total of 210 PwCI-CG dyads were enrolled into the study. The most successful recruitment sources for making initial contact, reaching, screening, and enrolling eligible dyads were a healthcare system database and a volunteer participant registry (46% and 37%, respectively). Future studies should consider utilizing healthcare system databases and state-volunteer participant registries when conducting dyadic recruitment, as these sources greatly improved initial outreach and enrollment rates. gov ID NCT04515875.

Concepts Keywords
Covid Caregivers
Healthcare Cognitive impairment
Nct04515875 Community-based
Pandemic Dyads
Recruiting Recruitment
Recruitment strategies

Semantics

Type Source Name
drug DRUGBANK Spinosad
disease MESH cognitive impairment
disease MESH COVID-19 pandemic

Original Article

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