Publication date: Jun 06, 2026
Decompensated cirrhosis is associated with high in-hospital mortality, influenced by disease severity and underlying etiology. The COVID-19 pandemic may have altered both the etiological spectrum and clinical presentation of hospitalized patients. This study aimed to assess longitudinal changes in etiology and identify predictors of in-hospital mortality over a 10-year period. We conducted a retrospective cohort study including 812 patients hospitalized with decompensated liver cirrhosis between 2015 and 2025. Patients were grouped into pre-COVID-19 (2015-2019), COVID-19 (2020-2021) and post-COVID-19 (2022-2025) periods. Etiological factors and mortality rates were compared using chi-square tests. Independent predictors were identified through multivariate analysis. A clinical risk score based on Child-Pugh stage, platelet count and age was developed and evaluated using ROC analysis. Alcohol-related cirrhosis increased significantly from 51. 2% (pre-COVID-19) to 90. 4% (COVID-19) and remained high post-COVID-19 (86. 3%) (p
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| Concepts | Keywords |
|---|---|
| Alcohol | alcohol-related cirrhosis |
| Liver | COVID-19 |
| Platelet | decompensated cirrhosis |
| Thrombocytopenia | liver cirrhosis |
| thrombocytopenia |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Cirrhosis |
| disease | MESH | COVID-19 |
| disease | MESH | liver cirrhosis |
| drug | DRUGBANK | Saquinavir |
| drug | DRUGBANK | Ethanol |
| disease | MESH | included |
| disease | MESH | thrombocytopenia |
| disease | MESH | Emergency |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | drd |
| disease | MESH | cytopenia |
| disease | MESH | alcoholic fatty liver |
| disease | MESH | NAFLD |
| disease | MESH | Portal hypertension |
| disease | MESH | bleeding |
| disease | MESH | hepatic encephalopathy |
| disease | MESH | peritonitis |
| disease | MESH | hepatorenal syndrome |
| disease | MESH | hepatocellular carcinoma |
| pathway | KEGG | Hepatocellular carcinoma |
| drug | DRUGBANK | Trestolone |
| disease | MESH | hepatitis |
| disease | MESH | infection |
| disease | MESH | liver disease |
| drug | DRUGBANK | Human Serum Albumin |
| disease | MESH | ascites |
| disease | MESH | death |