Publication date: Jun 30, 2026
Frontotemporal dementia (FTD) comprises a heterogeneous group of neurodegenerative syndromes with variable behavioral, cognitive, and language profiles. Longitudinal data describing its clinical course using FTD-specific instruments remain scarce. This study aimed to characterize the functional, cognitive, and behavioral trajectories of FTD subtypes in a Spanish cohort, including assessments performed remotely during the COVID-19 pandemic. Sixty-seven patients diagnosed with behavioral variant FTD (bvFTD), non-fluent variant primary progressive aphasia (nfvPPA), or semantic variant PPA (svPPA) were prospectively followed at Hospital Universitario 12 de Octubre (Madrid, Spain). Functional and neuropsychiatric status were evaluated using the Frontotemporal Dementia Rating Scale (FTD-FRS), the Interview for Deterioration in Daily Activities in Dementia (IDDD), the Neuropsychiatric Inventory (NPI), and the telephone Mini-Mental State Examination (T-MMSE). Thirty-three assessments were conducted remotely during pandemic restrictions. Over a mean follow-up of 3. 1 years, significant declines were found in T-MMSE, FTD-FRS, and IDDD (p
| Concepts | Keywords |
|---|---|
| Daily | Assessments |
| Dementia | Behavioral |
| Frs | Cognitive |
| Heterogeneous | Cohort |
| Spanish | Covid |
| Dementia | |
| Frontotemporal | |
| Ftd | |
| Functional | |
| Group | |
| Heterogeneous | |
| Longitudinal | |
| Pandemic | |
| Spain | |
| Variant |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Frontotemporal Dementia |
| disease | MESH | COVID-19 Pandemic |
| disease | MESH | syndromes |
| disease | MESH | clinical course |
| disease | MESH | primary progressive aphasia |
| drug | DRUGBANK | Phenylpropanolamine |
| disease | MESH | PPA |
| disease | MESH | Dementia |
| disease | MESH | cognitive decline |