Staphylococcus aureus CC398 Lineage of the Human Clade Isolated from Bloodstream Infection and Colonization and Spread among Brazilian Patients Hospitalized during the COVID-19 Pandemic.

Publication date: Jun 30, 2026

Community lineages of Staphylococcus aureus emerging in hospitals, such as CC398, have raised concerns. S. aureus CC398 isolates from bloodstream infections (BSI) and nasal colonization of hospitalized patients, during the COVID-19 pandemic, between March/2020 and September/2021, were characterized for antimicrobial susceptibility by disk diffusion test. Spa types and Sequence Type (ST) were analyzed by PCR/sequencing, and genes of resistance, virulence, and human immune evasion cluster (IEC) were accessed by PCR. Of a total of 118 CC398 isolates, 104 were from nasal swabs (4 MRSA and 100 MSSA), and 14 MSSA were from BSI. Forty (33. 9%) patients presented COVID-19, and prior antimicrobial use was common among those colonized (p 

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Concepts Keywords
Colonization Adult
Pcr Aged
Staphylococcus Aged, 80 and over
Virulence Anti-Bacterial Agents
Anti-Bacterial Agents
Bacteremia
Brazil
COVID-19
Female
Humans
Male
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Middle Aged
Pandemics
SARS-CoV-2
Staphylococcal Infections
Staphylococcus aureus

Semantics

Type Source Name
disease MESH Bloodstream Infection
disease MESH COVID-19 Pandemic
disease MESH Thas
drug DRUGBANK Coenzyme M
drug DRUGBANK Ribostamycin
disease MESH Maca
disease MESH CEP
disease MESH Bacteremia
drug DRUGBANK Meticillin
disease MESH Staphylococcal Infections

Original Article

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