Publication date: Jun 29, 2026
The aim of our study was to compare the prevalence, etiology, and outcomes of sepsis and associated AKI in pre- and post-COVID-19 pandemic. We conducted a retrospective observational analysis in 144 patients with sepsis and AKI, in two periods of time, 2 years before and after COVID-19 pandemic, with 2 years’ washout period. The comparative analysis between the two periods demonstrated more severe forms of sepsis with septic shock dominating in the post pandemic period (5 (10%) vs 23 (25%), p = 0. 037). According AKI staging we found AKI stage 3 more frequently present after pandemic and more patients needed dialysis in the post COVID-19 pandemic (35 (70%) vs 79 (84%), p = 0. 04; 31 (62%) vs 78 (54%), p = 0. 02; 16 (32%) vs 51% (54%), p = 0. 018), respectively. Patients in post COVID-19 era survived less longer (22. 66 +/- 11. 32 vs 17. 132 +/- 12. 66, p = 0. 021) with almost doubled risk for mortality HR: 1. 977; 95% CI (1. 127 +/- 3. 469), p = 0. 018. Regarding causative agents’ there was similar distribution in both periods, but the multiple antibiotic resistance index (MAR) was significantly higher in the post COVID-19 period for Staphylococcus coagulase negative (0. 48 vs 0. 62, p = 0. 001). Sepsis and associated AKI occurrence, morbidity and mortality are significantly higher in the post COVID-19 pandemic and the increased MAR of the germs can be one of the main reason for it.
| Concepts | Keywords |
|---|---|
| Kidney | AKI |
| Microbiological | COVID-19 |
| Pandemic | dialysis |
| multiple antibiotic resistance | |
| sepsis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | sepsis |
| disease | MESH | acute kidney injury |
| disease | MESH | COVID-19 |
| disease | MESH | septic shock |
| disease | MESH | Long Covid |