Publication date: Jun 29, 2026
Vaccination against COVID-19 infection became mandatory because of the field situation during the pandemic. Vaccine efficacy and safety need many field years of study; time constraints due to the pandemic limited the same. A hospital-based study was done in South India among patients who presented with immune-mediated disorders in temporal correlation with COVID-19 vaccination. The study period was 20 months, from March 2020 to November 2021. There were a total of 3,235 patients with neurological issues seen in two tertiary institutions, catering predominantly to patients from lower socio-economic strata in South India. A total of 1,007 (31. 12%) patients had received COVID-19 vaccination (single dose in 511 [50. 7%] and both doses in 496 [49. 3%]). The general prevalence of primary demyelinating disease was compared with the background of vaccine-induced demyelination. Chi-square test was utilised for determining the association between neurological sequelae and the type of vaccine administered. Eighteen patients had neurological sequelae, and 16 had a monophasic pattern. Recurrent autoimmunity was seen in two patients who took the Sputnik vaccine. Comparing the prevalence of primary multiple sclerosis (MS) versus vaccine-induced demyelination, there was a statistically significant difference (χ = 572. 38; p
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| Concepts | Keywords |
|---|---|
| Fatal | COVID-19 |
| Glycoprotein | immune dysregulation |
| March | sequelae |
| Vaccination | vaccination |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID-19 |
| disease | MESH | infection |
| disease | MESH | demyelinating disease |
| disease | MESH | multiple sclerosis |
| disease | MESH | neurological manifestations |
| disease | MESH | optic neuritis |
| disease | MESH | ulcerative colitis |
| disease | MESH | arthritis |