Publication date: Jul 01, 2026
Understanding the determinants that influence parents’ decisions to participate with their infants in primary prevention trials is essential for achieving representative study samples and ensuring the generalizability of outcomes. We analyzed quantitative and qualitative data collected from infants eligible for the Primary Oral Insulin Trial (N=2,750) or the Supplementation with B. INfantis for Mitigation of Type 1 Diabetes Autoimmunity Trial (N=3,309). Both trials were conducted within the Global Platform for the Prevention of Autoimmune Diabetes between 07/2017 and 04/2024. Among all eligible infants, a longer decision time (odds ratio: 1. 01, 95% confidence interval: 1. 00-1. 01, and p=0. 002), having a first-degree relative with type 1 diabetes (odds ratio: 2. 18, 95% confidence interval: 1. 95-2. 43, and p
| Concepts | Keywords |
|---|---|
| Diabetes | Confidence |
| Global | Determinants |
| Mitigation | Diabetes |
| Parents | Eligible |
| Infant | |
| Infants | |
| Interval | |
| Non | |
| Odds | |
| Participation | |
| Prevention | |
| Primary | |
| Ratio | |
| Trial | |
| Trials |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Type 1 Diabetes |