Publication date: Jul 03, 2026
Influenza and pneumonia associated sepsis contribute markedly to mortality among the older adults in the United States. Yet, the long-term mortality trajectories and demographic and geographic heterogeneity have not been well characterized. We used the CDC WONDER database to identify deaths involving influenza- and pneumonia-associated sepsis among U. S. adults aged ≥65 years from 1999 to 2022 and applied Joinpoint regression to assess temporal changes in mortality trends. From 1999 to 2022, a total of 730,918 deaths involving influenza and pneumonia associated sepsis were identified among older adults in the United States. Overall mortality exhibited an initially stable pattern followed by a sustained increase, peaking during the COVID-19 pandemic, and subsequently declining slightly but remaining at a relatively high level. Among older adults, the age-adjusted mortality rate (AAMR) rose from 68. 96 in 1999 to 81. 89 in 2022, with the steepest increase during 2011-2022 (APC=3. 63, 95% CI 2. 20-5. 07; p
| Concepts | Keywords |
|---|---|
| Covid | Adultos mayores |
| Pneumonia | CDC WONDER |
| Steepest | Influenza |
| Mortality trends | |
| Neumonía | |
| Older adults | |
| Pneumonia | |
| Sepsis | |
| Tendencias de mortalidad |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | influenza |
| disease | MESH | pneumonia |
| disease | MESH | sepsis |
| disease | MESH | COVID-19 pandemic |
| disease | MESH | AAMR |