Publication date: Aug 01, 2026
Post-COVID-19 syndrome encompasses persistent cognitive, neurological, and psychiatric symptoms following SARS-CoV-2 infection, profoundly affecting global quality of life. Clarifying the neurobiological basis of these symptoms is vital for effective therapeutic interventions. This study utilized normative modelling of brain structure (“CentileBrain”) to quantify subject-level deviations in cortical thickness, surface area, and subcortical volumes among 20 patients experiencing persistent fatigue following mild COVID-19, compared to 20 matched healthy controls. Group-level analyses on deviation scores revealed subtle yet distinct regional alterations in cortical thickness, specifically decreased thickness within orbitofrontal cortices and increased thickness in occipital/sensory cortices. Although at the individual regional level, the proportion of patients exhibiting infranormal or supranormal thickness values was relatively low (
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | COVID19 |
| disease | MESH | syndrome |
| disease | MESH | Post-COVID-19 syndrome |
| pathway | REACTOME | SARS-CoV-2 Infection |
| disease | MESH | fatigue |