Genetic Variants in NOS2 and CCL2 Modulate Risk of Post-COVID-19 Hyperglycemia via Immune-Metabolic Interactions.

Publication date: Jul 07, 2026

Hyperglycemia has increasingly been recognized among individuals recovering from coronavirus disease 2019 (COVID-19); the host factors contributing to heterogeneous metabolic outcomes remain poorly understood. This cohort study investigated the association between innate immune genetic polymorphisms and hyperglycemia in post-COVID-19 patients. A total of 471 adults with previous mild-to-moderate COVID-19 were enrolled through the post-COVID follow-up program at Siriraj Hospital, Thailand, and classified as normoglycemic (HbA1c 

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Concepts Keywords
Biomed Adult
Coronavirus Aged
Hyperglycemia CCL2 protein, human
Recovering Chemokine CCL2
Thailand Chemokine CCL2
COVID-19
COVID-19
Female
genetic polymorphism
Genotype
Humans
Hyperglycemia
hyperglycemia
Immunity, Innate
Male
Middle Aged
NOS2 protein, human
Polymorphism, Single Nucleotide
postviral diabetes
Risk Factors
SARS-CoV-2

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Hyperglycemia
disease MESH Obesity
disease MESH inflammation
drug DRUGBANK Methyl isocyanate
disease MESH Genetic Predisposition to Disease
drug DRUGBANK Nitric Oxide

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