Publication date: Aug 01, 2026
Due to increasing proportion of asymptomatic severe acute respiratory syndrome coronavirus 2 infections and previously reported overlapping features, the distinction between Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) remains challenging. Statistical differentiation models for clinical guidance are scarce and should focus on cardiac involvement, as differences in cardiac involvement might serve as a potential clinical finding for early recognition of MIS-C. We retrospectively analyzed 298 MIS-C and KD cases treated during the 22-year period (from 2003 to 2024), and compared demographic, clinical, laboratory, ultrasound and cardiac findings. A multivariable differentiation model based on clinical, laboratory, ultrasound and cardiac features was developed for distinguishing KD/MIS-C cases. Of 298 cases, 162 (54. 4%) were diagnosed with KD. MIS-C patients were significantly older (109. 1 vs. 45. 5 months, P
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Kawasaki Disease |
| disease | MESH | severe acute respiratory syndrome |
| disease | MESH | infections |
| disease | MESH | multisystem inflammatory syndrome in children |
| disease | MESH | Rash |
| disease | MESH | conjunctivitis |
| disease | MESH | Pericarditis |
| disease | MESH | congestive heart failure |
| disease | MESH | mitral regurgitation |
| disease | MESH | hyponatremia |
| disease | MESH | ascites |
| disease | MESH | COVID-19 |
| disease | MESH | Systemic Inflammatory Response Syndrome |