Publication date: Jul 23, 2026
Nanodecoys that competitively inhibit viral entry represent a promising antiviral strategy, yet the influence of their physical properties on performance remains underexplored. In this work, we systematically investigate the size-dependent antiviral activity of ACE2-conjugated nanodecoys against a safe SARS-CoV-2 mimic. Our results demonstrate that the inhibition of mimic cellular uptake is highly size-dependent. The 10 nm nanodecoys exhibited the most potent neutralization, followed by the comparable 5 and 20 nm, while the 50 and 100 nm nanodecoys demonstrated similar, lower efficacies. This work identifies nanodecoy size as a critical design principle, providing a rational framework for engineering high-performance antiviral nanotherapeutics to combat SARS-CoV-2 and other viral pathogens.
| Concepts | Keywords |
|---|---|
| 100nm | antiviral |
| Antiviral | nanodecoy |
| Competitively | neutralization |
| Nanotherapeutics | SARS‐CoV‐2 mimic |
| Viral | size‐dependent |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Infection |