Value of quantitative SARS-CoV-2 spike antibodies in assessing risk of severe COVID-19: A retrospective cohort study.

Publication date: Aug 01, 2026

Since coronavirus disease 2019 (COVID-19) pandemic, its variants have challenged vaccine effectiveness and immunity, particularly among high-risk individuals. Assessment of the risk of severe COVID-19 in these populations is crucial for informed therapeutic decisions. We aim to correlate early quantitative SARS-CoV-2 spike antibody (S ab) levels in SARS-CoV-2 infections with the risk of severe COVID-19. We conducted a retrospective cohort study of hospitalized patients with early-stage COVID-19 and S ab titers between April 2021 and June 2022. S ab titers were stratified into four categories:

Concepts Keywords
Adult
Aged
Antibodies
Antibodies, Viral
Antibodies, Viral
COVID-19
COVID-19
Female
Humans
Immunity
Male
Middle Aged
Retrospective Studies
SARS-CoV-2
SARS-CoV-2
Spike Glycoprotein, Coronavirus
Spike Glycoprotein, Coronavirus
Spike protein
spike protein, SARS-CoV-2

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Long Covid

Original Article

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