Publication date: Jul 06, 2026
Medical image segmentation is critical for clinical diagnosis, yet existing methods face a persistent trade-off: CNN-based approaches are constrained by local receptive fields, while Transformer-based methods suffer from semantic dilution when modeling global context. To address these limitations, we propose SCAGC-UNet, a region-aware graph convolutional network that bridges local detail extraction and global dependency modeling through structured region-level reasoning. The architecture features a dual-layer residual encoder for hierarchical feature extraction and a Spatial-Channel Graph Convolution (SC-GCN) module at the bottleneck, which simultaneously captures inter-region spatial topology and intra-region channel semantics via dual-branch graph inference. Feature refinement in the decoder is further enhanced by Context-Corrected Modules and Backward-Aided Modules to reduce the semantic gap across skip connections. We validate SCAGC-UNet on three public benchmarks covering distinct imaging challenges. On Kvasir-SEG, the model achieves a Dice score of 92. 28% and MIOU of 92. 41%, surpassing the strongest CNN-based baseline CCBANet by 0. 73% in DSC and outperforming TransUNet by 11. 76% in DSC. On BUSI, it attains an IOU of 78. 10% and MIOU of 87. 68%, outperforming UNet by 2. 82% in IOU and TransUNet by 6. 91% in DSC. On COVID-19 CT, it achieves a DSC of 82. 51%, surpassing UNet by 4. 99% and TransUNet by 7. 47%, demonstrating robust performance on irregular lesion morphologies. These results confirm that SCAGC-UNet achieves consistent and robust segmentation performance across three public benchmark datasets spanning distinct imaging modalities, suggesting its potential clinical relevance.
Open Access PDF
| Concepts | Keywords |
|---|---|
| Bottleneck | graph convolutional networks |
| Cnn | medical image segmentation |
| Ct | spatial-channel attention |
| Informatics |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Image |
| disease | MESH | face |
| disease | MESH | COVID-19 |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | plan |
| drug | DRUGBANK | Spinosad |
| drug | DRUGBANK | Flunarizine |
| disease | MESH | tumor |
| drug | DRUGBANK | Trinitrotoluene |
| disease | MESH | OS2 |
| disease | MESH | CCMs |
| disease | MESH | BAMs |
| disease | MESH | CCM |
| disease | MESH | gra |
| disease | MESH | included |
| disease | MESH | RCC |
| disease | MESH | colonic polyp |
| drug | DRUGBANK | Resiniferatoxin |
| disease | MESH | Acc |
| drug | DRUGBANK | Methionine |
| disease | MESH | polyp |
| drug | DRUGBANK | Isoxaflutole |
| disease | MESH | ers |
| disease | MESH | RDC |
| drug | DRUGBANK | Trestolone |
| pathway | REACTOME | Translation |
| drug | DRUGBANK | Sulpiride |
| disease | MESH | Lymph Node Metastasis |
| drug | DRUGBANK | Guanosine |
| drug | DRUGBANK | (S)-Des-Me-Ampa |
| disease | MESH | Brain Tumor |
| disease | MESH | injury |