Evaluation of short-term multi-target respiratory forecasts over winter 2024-25 in England using sub-ensemble contribution analyses.

Evaluation of short-term multi-target respiratory forecasts over winter 2024-25 in England using sub-ensemble contribution analyses.

Publication date: Aug 12, 2026

Epidemic forecasting research often assesses ensembles and their component models using probabilistic scoring rules. Quantifying how individual models affect ensemble performance is challenging, particularly across multiple targets and spatial scales. We present Winter 2024-25 forecasts of Influenza and COVID-19 hospital admissions in England and conduct a retrospective simulation using the operational component models. Forecasts were scored using the per capita weighted interval score (pcWIS) for counts and the ranked probability score (RPS) for ordinal trend direction. We compared retrospective forecasts, used generalised additive models (GAMs) to estimate the expected change in score from the inclusion of a model in a sub-ensemble (an ensemble formed from a subset of available models), and used Pareto analysis to understand which sub-ensembles were Pareto-optimal across scoring rules. Nationally, there was a 47% improvement in Influenza pcWIS versus sub-ensembles. However, Influenza operational ensembles were on average 22% worse than sub-ensembles, when measured by RPS. For COVID-19, operational ensembles were 43% and 280% worse on average, than retrospective sub-ensembles by pcWIS and RPS, respectively. However, COVID-19 operational ensembles were on average 2% (pcWIS) and 13% (RPS) better than individual operational models. For influenza, operational ensembles were, on average, 58% (pcWIS) and 41% (RPS) better than individual models. The sub-ensemble simulation showed how individual models influenced the ensemble scores during different epidemic phases. The Pareto analysis demonstrated that there can be a trade-off between relative direction and absolute count score optimisation.

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Concepts Keywords
Average
Covid
Ensemble
Ensembles
Forecasts
Individual
Influenza
Models
Operational
Pareto
Pcwis
Retrospective
Rps
Score
Sub

Semantics

Type Source Name
disease MESH Influenza
disease MESH COVID-19
drug DRUGBANK Tropicamide
drug DRUGBANK Coenzyme M
disease MESH emergency
disease MESH bed
disease MESH infectious diseases
disease MESH NHS
pathway REACTOME Reproduction
drug DRUGBANK Huperzine B
disease MESH included
drug DRUGBANK Etoperidone
drug DRUGBANK Ranitidine
disease MESH dis
disease MESH infections
disease MESH plan
disease MESH measles
pathway KEGG Measles
disease MESH mpox
disease MESH emerging infectious disease
drug DRUGBANK Aspartame
drug DRUGBANK Serine
disease MESH dengue

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