Publication date: Aug 03, 2026
Background/Objectives: Long COVID is frequently characterized by neurological, cognitive, neuropsychiatric, and autonomic symptoms (NeuroCOVID). However, their impact on daily functioning remains insufficiently investigated. This study evaluated the association between NeuroCOVID burden and functional impairment among Italian Long COVID survivors. Methods: A secondary cross-sectional analysis was conducted on 250 adults using a validated Italian Long COVID questionnaire. A NeuroCOVID Burden Score (10 symptom domains) and a Functional Impairment Score (daily activities) were constructed and analyzed using correlation and multivariable linear regression. Results: The sample (mean age 33. 2 years; 63. 6% female) demonstrated high internal consistency for both scores. A strong positive correlation was found between NeuroCOVID burden and functional impairment (r = 0. 703; p
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| Concepts | Keywords |
|---|---|
| cognitive dysfunction | |
| functional impairment | |
| Long COVID | |
| NeuroCOVID | |
| Post-COVID-19 Condition | |
| public health | |
| rehabilitation | |
| SARS-CoV-2 |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Long COVID |
| disease | MESH | COVID-19 |
| drug | DRUGBANK | Coenzyme M |
| drug | DRUGBANK | L-Aspartic Acid |
| disease | MESH | cognitive dysfunction |
| drug | DRUGBANK | Factor IX Complex (Human) |
| disease | MESH | PCC |
| disease | MESH | neurological manifestations |
| disease | MESH | headache |
| disease | MESH | dys |
| disease | MESH | brain fog |
| disease | MESH | anxiety |
| disease | MESH | dysautonomia |
| disease | MESH | acute disease |
| disease | MESH | infection |
| disease | MESH | neuroinflammation |
| disease | MESH | fatigue |
| disease | MESH | musculoskeletal pain |
| disease | MESH | included |
| drug | DRUGBANK | Pentaerythritol tetranitrate |
| disease | MESH | tinnitus |
| disease | MESH | dysphonia |
| disease | MESH | sleep disorders |
| disease | MESH | mood disorders |
| disease | MESH | tachycardia |
| disease | MESH | reinfection |
| disease | MESH | cognitive symptoms |