Myocardial T1 and T2 Mapping at 5.0T: Feasibility and Comparison with 3.0-T MRI.

Publication date: Aug 17, 2026

Myocardial T1 and T2 mapping provide a non-invasive quantitative assessment of cardiac tissue. While established at 1. 5-T and 3. 0-T MRI, the mapping performance and reference values at 5. 0-T MRI remain to be investigated. This study aims to evaluate the feasibility and establish reference values for cardiac T1 and T2 mapping at 5. 0-T MRI in healthy subjects. In this prospective study, 50 healthy volunteers underwent cardiovascular magnetic resonance at both 3. 0-T and 5. 0-T systems from February to April 2025. Mapping protocols included MOdified Look Locker Inversion recovery (MOLLI, T1), T2-prepared gradient-echo (T2-prep-GRE, T2), and a simultaneous multi-parametric mapping technique (Multimap, T1 and T2). At 3. 0-T MRI, both balanced steady-state free precession (bSSFP) and fast low-angle shot (FLASH) readouts were employed, while only the FLASH readout was used at 5. 0-T MRI. Segment exclusion rates were analyzed at the subject-level using nonparametric tests with Holm correction for multiple comparisons. Measurement repeatability (intra-observer, scan-rescan) and reproducibility (inter-observer) were assessed by coefficient of variation (CoV), repeatability coefficient (RC), and intraclass correlation coefficient (ICC). Systematic difference and agreement between repeated measurements were evaluated using Bland-Altman analysis. Group-level variability was described by mean +/- SD across subjects. Group comparisons were performed with repeated measures ANOVA. All techniques at 5. 0-T MRI yielded high-quality images that were predominantly free of visible artifacts with the FLASH readout. After quality control, segment acceptance rates ranged from 87. 8% to 94. 0%, and matched FLASH-readout comparisons showed higher exclusion rates at 5. 0T than at 3. 0T (all P

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