Publication date: Dec 01, 2026
Non-alcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM) are increasingly prevalent, interrelated conditions contributing significantly to morbidity and mortality. Understanding long-term mortality trends is essential to guide public health strategies. This study aimed to evaluate nationwide mortality trends involving NAFLD and DM in the United States from 1999 to 2022 and to assess demographic and geographic disparities. CDC WONDER was used to extract data for adults aged ≥ 25 years. 10th Revision (ICD-10), using the explicit codes with K74. 0, K74. 6, K75. 8, K76. 0 and K76. 9 for NAFLD and E10-E14 for DM. Age- Adjusted Mortality Rates (AAMRs) per million population were calculated and trends were analyzed by calculating annual percent change (APC) and the average annual percent change (AAPC) using Joinpoint Regression Program (version 5. 2.0. 0; National Cancer Institute), with statistical significance set at p
| Concepts | Keywords |
|---|---|
| CDC WONDER | |
| Diabetes mellitus (DM) | |
| Mortality | |
| Trends |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | non-alcoholic fatty liver disease |
| pathway | KEGG | Non-alcoholic fatty liver disease |
| disease | MESH | diabetes mellitus |
| disease | MESH | ICD |
| disease | MESH | APC |
| disease | MESH | Cancer |