Pre-pandemic preventive healthcare engagement and all-cause excess mortality during COVID-19: a county-level ecological study in the United States.

Pre-pandemic preventive healthcare engagement and all-cause excess mortality during COVID-19: a county-level ecological study in the United States.

Publication date: Aug 23, 2026

Community resilience during COVID-19 has been linked to social conditions, public-health capacity, and acute-care resources, but the contribution of pre-pandemic realized preventive-care engagement remains incompletely characterized. We examined whether county-level preventive-care engagement was associated with all-cause excess mortality during the COVID-19 period in the United States. In this ecological study, county-specific linear trends fitted to the age-adjusted all-cause premature-death/YPLL-75 indicator for 2012-2018 were used to predict expected mortality in 2020-2022. Excess mortality was the percentage difference between observed and expected values; resilience was its negative. We estimated adjusted associations for four preventive-care indicators using five-fold cross-fitted double/debiased machine learning (DML), with learner, fold, state-clustered, external-demographic, and spatial lag/error sensitivities. Across 3,079 counties, mean excess mortality in 2020-2022 was 15. 2%. In the primary DML sample (n=2,921), one-standard-deviation higher influenza-vaccination and mammography-screening rates were associated with 0. 106 SD (p

Concepts Keywords
All-cause excess mortality
COVID-19
Double machine learning
Ecological study
Health disparities
Mortality resilience
Preventive healthcare
Spatial epidemiology

Semantics

Type Source Name
disease MESH COVID-19
disease MESH death
disease MESH influenza

Original Article

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