A Practical Review of Adaptive Platform Trials.
Publication date: Nov 19, 2025Traditional randomized controlled trials (RCTs) can provide rigorous evidence but are ...
Clinical Trials
Information on Covid-19 clinical trials
-
-
Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial.
Publication date: Nov 29, 2025Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including ... -
“If I am here, it is because the system failed”: a critical qualitative study of global commercial clinical trials for advanced cancer in Chile.
Publication date: Nov 28, 2025The pharmaceutical industry is a key global health actor given its ... -
Experiences with Qi and changes in post-acute sequelae of COVID-19 (PASC) symptoms with qigong: a qualitative analysis of participants’ experiences in a pilot clinical trial.
Publication date: Nov 28, 2025Commonly known as “long COVID”, post-acute sequelae of COVID-19 (PASC) is ... -
Immunogenicity and Safety of Half and Full Doses of Heterologous and Homologous COVID-19 Vaccine Boosters After Priming with ChAdOx1 in Adult Participants in Indonesia: A Single-Blinded Randomized Controlled Trial.
Publication date: Nov 11, 2025Background: Numerous studies have proved the efficacy of vaccination in reducing ... -
Digital Storytelling to Reduce Hispanic Parents’ COVID-19 Vaccine Hesitancy: A Pilot Randomized Controlled Trial.
Publication date: Oct 24, 2025Hispanic children in the U. S. experience disproportionately low COVID-19 vaccination ... -
Efficacy of the Web-Based Gamified Infection Control Training System on Practices for Health Care Workers in Residential Care Homes: Clustered Randomized Controlled Trial.
Publication date: Nov 27, 2025Staff working in residential care homes (RCHs) have played a significant ... -
Effect of Motion-Controlled Video Games-Based Virtual Reality Exercise on Patients with Post-COVID-19 Condition: A Randomized Controlled Trial.
Publication date: Nov 14, 2025Objective: Virtual reality (VR) exercises may offer a comprehensive rehabilitation approach ... -
Retifanlimab versus placebo in combination with platinum-based chemotherapy in patients with first-line non-squamous or squamous metastatic non-small-cell lung cancer (POD1UM-304): a phase 3, multiregional, placebo-controlled, double-blind, randomised study.
Publication date: Dec 01, 2025Checkpoint inhibitors, including combinations with standard-of-care chemotherapy, have shown survival benefit ... -
SISAQOL-IMI consensus-based guidelines to design, analyse, interpret, and present patient-reported outcomes in cancer clinical trials.
Publication date: Dec 01, 2025Standardising the implementation of patient-reported outcomes (PROs) in clinical trials is ... -
Phase 1 Randomized Controlled Trial of the Safety and Immunogenicity of the SARS-CoV-2 (Omicron BA.5) mRNA-CR-04 Vaccine in Adults 18-49 Years of Age.
Publication date: Dec 01, 2025This study (NCT05972993) evaluated a novel mRNA vaccine construct using the ... -
Antiviral clinical trial design throughout the COVID pandemic: evolving endpoints and lessons learnt.
Publication date: Nov 28, 2025Trial design during the novel coronavirus-19 (COVID-19) pandemic was stymied by ... -
Profile of clinical trials with drugs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Spain.
Publication date: Nov 27, 2025On 11 March 2020, World Health Organisation declared COVID-19 a pandemic. ... -
Incidence of stroke following COVID-19 vaccination: a nationwide self-controlled risk interval study in Qatar.
Publication date: Nov 26, 2025This study assessed short-term stroke risk following COVID-19 vaccination using Qatar’s ... -
Identifying Barriers and Motivators to Increase Surgical Clinical Trial Participation for Older Veterans.
Publication date: Nov 26, 2025Patients aged 65+ are underrepresented in surgical clinical trials, and few ... -
Workplace stressors and burnout among healthcare professionals: Insights from the pandemic and implications for future public health crises.
Publication date: Nov 26, 2025This study evaluates the prevalence of burnout among healthcare professionals (HCPs) ... -
‘Lessons learned’ from trialists who adapted a complex intervention for remote delivery within a trial as a result of the COVID-19 pandemic: a scoping review.
Publication date: Nov 25, 2025During the COVID-19 pandemic, complex interventions being evaluated in randomised controlled ... -
One year follow up of phase 1/2 randomized, placebo controlled trial of NDV-HXP-S vaccine in Thailand.
Publication date: Nov 25, 2025To promote self-reliance in vaccine production, a chimeric Newcastle Disease Virus ... -
Treatment of Non-severe COVID-19 with Molnupiravir: A Systematic Review with Meta-analysis and Trial Sequential Analysis of the Evidence from Randomized Controlled Trials.
Publication date: Nov 25, 2025BACKGROUND AND OBJECTIVE: The evidence on molnupiravir for the treatment of ... -
Simulation-Based Bayesian Predictive Probability of Success for Interim Monitoring of Clinical Trials With Competing Event Data: Two Case Studies.
Publication date: Oct 07, 2025Bayesian predictive probabilities of success (PPoS) use interim trial data to ... -
Using a mental model approach to undercut the effects of exposure to mRNA vaccination misconceptions: Two randomized trials.
Publication date: Dec 02, 2025Although messenger RNA (mRNA) technology revolutionized vaccine creation, its use is ...